MolNFT v1 · #152873 · protein
Crystal structure of the LIN28-interacting module of human TUT4
6IW6 · Terminal uridylyltransferase 4,TERMINAL uridylyltransferase…: “Crystal structure of the LIN28-interacting module of human TUT4”. X-ray diffraction, 1 ligand (ZN), 9 pockets (best druggability 0.78). MolNFT v1 #152873 on GenesisL1…
- PDB
- 6IW6
- Type
- protein
- Length
- 876 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Terminal uridylyltransferase 4,TERMINAL uridylyltransferase 4
- EC
- 2.7.7.52
- UniProt
- Q5TAX3
- Ligands
- ZN
- Pockets
- 9 · best druggability 0.78
Structure
x-ray diffraction · 1 distinct chain · 43% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Terminal uridylyltransferase 4,TERMINAL uridylyltransferase 4 (EC 2.7.7.52) | protein | 438 | 43% helix, 16% strand | Q5TAX3 |
Ligands and binding sites
- ZN · Zinc ion · metal · 4 copies · chains A, B
- EDO · 1,2-ethanediol · additive · 8 copies · chains A, B
- FLC · Citrate anion · additive · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
9 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 382 | 0.78 | 0.88 | 43 | EDO |
| 2 | 382 | 0.78 | 0.88 | 44 | empty |
| 3 | 274 | 0.55 | 0.76 | 51 | empty |
| 4 | 191 | 0.48 | 0.75 | 42 | empty |
| 5 | 138 | 0.44 | 0.76 | 19 | empty |
Interfaces
1 interface between chains.
- A–B · 379 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 6IW6 · Crystal structure of the Lin28-interacting module of human TUT4 · the same entry in another collection · chain A against A, TM-score 1.00
- Q5TAX3 · AlphaFold monomer V2.0 prediction for terminal uridylyltransferase 4 (Q5TAX3) · a predicted model of the same protein · chain A against A, TM-score 0.93
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q5TAX3
- Elsewhere: RCSB PDB 6IW6 · PDBe 6IW6 · UniProt Q5TAX3
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