MolNFT v1 · #152842 · protein + RNA

Cryo-EM structure of ACRVA5-acetylated MBCAS12A in complex with crrna

6IV6 · Nuclease: “Cryo-EM structure of ACRVA5-acetylated MBCAS12A in complex with crrna”. Electron microscopy, 20 pockets (best druggability 0.77). MolNFT v1 #152842 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6IV6
Type: protein + RNA
Length: 1,235 residues
Chains: 2
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Nuclease; RNA (59-mer)
UniProt: A0A0U2B2X7
Pockets: 20 · best druggability 0.77

Structure

electron microscopy · 2 distinct chains · 34% helix, 11% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Nuclease	protein	1209	34% helix, 11% strand	A0A0U2B2X7
G	RNA (59-mer)	rna	26	—	—

Pockets

20 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	673	0.77	0.82	60	empty
2	908	0.76	0.79	81	empty
3	106	0.74	0.94	32	empty
4	538	0.65	0.77	53	empty
5	50	0.65	0.97	14	empty

Interfaces

1 interface between chains.

A–G · 2974 Å² buried · 54 hydrogen bonds · protein-nucleic

Modifications

Observed in the structure: 4 modified (acetylation).

Compared structures

6IV6 · Cryo-EM structure of AcrVA5-acetylated MbCas12a in complex with crRNA · the same entry in another collection · chain G against G, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A0A0U2B2X7
Elsewhere: RCSB PDB 6IV6 · PDBe 6IV6 · UniProt A0A0U2B2X7

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.