MolNFT v1 · #152831 · protein

A higher kcat rubisco

6IUS · Ribulose-1,5-bisphosphate CARBOXYLASE/OXYGENASE: “A higher kcat rubisco”. X-ray diffraction, 10 pockets (best druggability 0.83). MolNFT v1 #152831 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6IUS
Type: protein
Length: 1,267 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Ribulose-1,5-bisphosphate CARBOXYLASE/OXYGENASE
UniProt: O68486
Pockets: 10 · best druggability 0.83

Structure

x-ray diffraction · 3 distinct chains · 41% helix, 19% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Ribulose-1,5-bisphosphate CARBOXYLASE/OXYGENASE	protein	426	42% helix, 18% strand	O68486
B	Ribulose-1,5-bisphosphate CARBOXYLASE/OXYGENASE	protein	419	42% helix, 19% strand	O68486
C	Ribulose-1,5-bisphosphate CARBOXYLASE/OXYGENASE	protein	422	40% helix, 18% strand	O68486

Pockets

10 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	157	0.83	0.98	40	empty
2	907	0.82	0.84	108	empty
3	503	0.64	0.77	55	empty
4	455	0.63	0.77	52	empty
5	384	0.61	0.77	45	empty

Interfaces

3 interfaces between chains.

A–C · 3010 Å² buried · 49 hydrogen bonds · protein-protein
B–C · 1050 Å² buried · 12 hydrogen bonds · protein-protein
A–B · 119 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

6IUS · A higher kcat Rubisco · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O68486
Elsewhere: RCSB PDB 6IUS · PDBe 6IUS · UniProt O68486

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.