MolNFT v1 · #152821 · protein
Crystal structure of GIT1 pbd domain in complex with paxillin LD4 motif
6IUI · Arf GTPase-activating protein GIT1: “Crystal structure of GIT1 pbd domain in complex with paxillin LD4 motif”. X-ray diffraction, 3 pockets (best druggability 0.57). MolNFT v1 #152821 on GenesisL1: 3D structure, binding sites and…
- PDB
- 6IUI
- Type
- protein
- Length
- 275 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Arf GTPase-activating protein GIT1; Paxillin
- UniProt
- Q9Z272, B4DRY6
- Pockets
- 3 · best druggability 0.57
Structure
x-ray diffraction · 4 distinct chains · 81% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Arf GTPase-activating protein GIT1 | protein | 119 | 79% helix, 0% strand | Q9Z272 |
| B | Arf GTPase-activating protein GIT1 | protein | 113 | 81% helix, 0% strand | Q9Z272 |
| C | Paxillin | protein | 22 | 91% helix, 0% strand | B4DRY6 |
| D | Paxillin | protein | 21 | 86% helix, 0% strand | B4DRY6 |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 319 | 0.57 | 0.76 | 37 | empty |
| 2 | 65 | 0.40 | 0.80 | 16 | empty |
| 3 | 59 | 0.26 | 0.73 | 12 | empty |
Interfaces
3 interfaces between chains.
- B–C · 831 Ų buried · 6 hydrogen bonds · protein-protein
- A–D · 805 Ų buried · 4 hydrogen bonds · protein-protein
- A–B · 280 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
- 6IUI · Crystal structure of GIT1 PBD domain in complex with Paxillin LD4 motif · the same entry in another collection · chain A against A, TM-score 1.00
- Q9Z272 · AlphaFold monomer V2.0 prediction for arf GTPase-activating protein GIT1 (Q9Z272) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9Z272
- Every structure of UniProt B4DRY6
- Elsewhere: RCSB PDB 6IUI · PDBe 6IUI · UniProt Q9Z272 · UniProt B4DRY6
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