MolNFT v1 · #152818 · protein

Crystal structure of anti-CRISPR protein ACRVA5

6IUF · Protein-a: “Crystal structure of anti-CRISPR protein ACRVA5”. X-ray diffraction, 1 ligand (ACO), 3 pockets (best druggability 0.69). MolNFT v1 #152818 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6IUF
Type: protein
Length: 191 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Protein-a
UniProt: A0A0U2B867
Ligands: ACO
Pockets: 3 · best druggability 0.69

Structure

x-ray diffraction · 2 distinct chains · 27% helix, 34% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Protein-a	protein	96	27% helix, 33% strand	A0A0U2B867
B	Protein-a	protein	95	27% helix, 34% strand	A0A0U2B867

Ligands and binding sites

ACO · Acetyl coenzyme *A · ligand · 2 copies · chains A, B
GOL · Glycerol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	242	0.69	0.85	41	empty
2	192	0.69	0.87	29	ACO
3	205	0.66	0.85	30	ACO

Interfaces

1 interface between chains.

A–B · 1036 Å² buried · 5 hydrogen bonds · protein-protein

Compared structures

6IUF · Crystal structure of Anti-CRISPR protein AcrVA5 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A0A0U2B867
Elsewhere: RCSB PDB 6IUF · PDBe 6IUF · UniProt A0A0U2B867

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.