MolNFT v1 · #152798 · protein
Crystal structure of the GULP1 ptb domain-app peptide complex
6ITU · Ptb domain-containing engulfment adapter protein 1: “Crystal structure of the GULP1 ptb domain-app peptide complex”. X-ray diffraction, 1 ligand (SO4), 2 pockets (best druggability 0.51). MolNFT v1 #152798 on GenesisL1: 3D…
- PDB
- 6ITU
- Type
- protein
- Length
- 158 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ptb domain-containing engulfment adapter protein 1; Amyloid beta A4 protein
- UniProt
- Q9UBP9
- Ligands
- SO4
- Pockets
- 2 · best druggability 0.51
Structure
x-ray diffraction · 2 distinct chains · 34% helix, 35% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Ptb domain-containing engulfment adapter protein 1 | protein | 146 | 34% helix, 36% strand | Q9UBP9 |
| B | Amyloid beta A4 protein | protein | 12 | 33% helix, 25% strand | — |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 117 | 0.51 | 0.81 | 17 | empty |
| 2 | 52 | 0.33 | 0.78 | 18 | empty |
Interfaces
1 interface between chains.
- A–B · 800 Ų buried · 11 hydrogen bonds · protein-protein
Compared structures
- 6ITU · Crystal Structure of the GULP1 PTB domain-APP peptide complex · the same entry in another collection · chain A against A, TM-score 1.00
- Q9UBP9 · AlphaFold monomer V2.0 prediction for ptb domain-containing engulfment adapter protein 1… · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9UBP9
- Elsewhere: RCSB PDB 6ITU · PDBe 6ITU · UniProt Q9UBP9
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