MolNFT v1 · #15278 · protein
Crystal structure of adenine phosphoribosyltransferase (aprt) from leishmania tarentolae
1MZV: “Crystal structure of adenine phosphoribosyltransferase (aprt) from leishmania tarentolae”. X-ray diffraction, 2 ligands (AMP, PO4), 2 pockets (best druggability 0.67). MolNFT v1 #15278 on GenesisL1: 3D structure, binding sites and…
- PDB
- 1MZV
- Type
- protein
- Length
- 216 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Adenine phosphoribosyltransferase
- EC
- 2.4.2.7
- UniProt
- O77103
- Ligands
- AMP, PO4
- Pockets
- 2 · best druggability 0.67
Structure
x-ray diffraction · 1 distinct chain · 37% helix, 26% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Adenine phosphoribosyltransferase (EC 2.4.2.7) | protein | 216 | 37% helix, 26% strand | O77103 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 444 | 0.67 | 0.79 | 49 | PO4, AMP |
| 2 | 68 | 0.38 | 0.79 | 15 | empty |
Compared structures
- 1MZV · Crystal Structure of Adenine Phosphoribosyltransferase (APRT) From Leishmania tarentolae · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O77103
- Elsewhere: RCSB PDB 1MZV · PDBe 1MZV · UniProt O77103
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