MolNFT v1 · #152767 · protein
Crystal structure of cx-4945 bound CK2 alpha from C. neoformans
6ISJ · Casein kinase II subunit alpha: “Crystal structure of cx-4945 bound CK2 alpha from C. neoformans”. X-ray diffraction, 2 ligands (3NG, SO4), 2 pockets (best druggability 0.67). MolNFT v1 #152767 on GenesisL1: 3D structure, binding…
- PDB
- 6ISJ
- Type
- protein
- Length
- 324 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Casein kinase II subunit alpha
- UniProt
- A0A226BA59
- Ligands
- 3NG, SO4
- Pockets
- 2 · best druggability 0.67
Structure
x-ray diffraction · 1 distinct chain · 41% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Casein kinase II subunit alpha | protein | 324 | 41% helix, 15% strand | A0A226BA59 |
Ligands and binding sites
- 3NG · 5-[(3-chlorophenyl)amino]benzo[c][2,6]naphthyridine-8-carboxylic acid · ligand · chains A
- SO4 · Sulfate ion · ion · 3 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 452 | 0.67 | 0.79 | 56 | 3NG, SO4 |
| 2 | 60 | 0.40 | 0.80 | 15 | empty |
Compared structures
- 6ISJ · Crystal structure of CX-4945 bound CK2 alpha from C. neoformans · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A226BA59
- Elsewhere: RCSB PDB 6ISJ · PDBe 6ISJ · UniProt A0A226BA59
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.