MolNFT v1 · #152760 · protein
Complex structure of MCD226-ecto and HCD155-D1
6ISC · CD226 antigen: “Complex structure of MCD226-ecto and HCD155-D1”. X-ray diffraction, 1 ligand (NAG), 3 pockets (best druggability 0.65). MolNFT v1 #152760 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6ISC
- Type
- protein
- Length
- 337 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- CD226 antigen; Poliovirus receptor
- UniProt
- Q8K4F0, P15151
- Ligands
- NAG
- Pockets
- 3 · best druggability 0.65
Structure
x-ray diffraction · 2 distinct chains · 4% helix, 48% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | CD226 antigen | protein | 219 | 4% helix, 46% strand | Q8K4F0 |
| B | Poliovirus receptor | protein | 118 | 3% helix, 53% strand | P15151 |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · chains B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 609 | 0.65 | 0.76 | 55 | empty |
| 2 | 129 | 0.56 | 0.83 | 21 | empty |
| 3 | 50 | 0.32 | 0.78 | 18 | empty |
Interfaces
1 interface between chains.
- A–B · 788 Ų buried · 10 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide, 1 glycan (disulfide, N-glycosylation).
Compared structures
- 6ISC · complex structure of mCD226-ecto and hCD155-D1 · the same entry in another collection · chain A against A, TM-score 1.00
- P15151 · AlphaFold monomer V2.0 prediction for poliovirus receptor (P15151) · a predicted model of the same protein · chain B against A, TM-score 0.99
- Q8K4F0 · AlphaFold monomer V2.0 prediction for CD226 antigen (Q8K4F0) · a predicted model of the same protein · chain A against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8K4F0
- Every structure of UniProt P15151
- Elsewhere: RCSB PDB 6ISC · PDBe 6ISC · UniProt Q8K4F0 · UniProt P15151
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.