MolNFT v1 · #152746 · protein

Crystal structure of the zebrafish cap-specific adenosine methyltransferase bound to sah

6IRY · PDX1 C-terminal-inhibiting factor 1: “Crystal structure of the zebrafish cap-specific adenosine methyltransferase bound to sah”. X-ray diffraction, 1 ligand (SAH), 3 pockets (best druggability 0.78). MolNFT v1 #152746 on GenesisL1…

PDB: 6IRY
Type: protein
Length: 468 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: PDX1 C-terminal-inhibiting factor 1
UniProt: A0A0R4IKJ1
Ligands: SAH
Pockets: 3 · best druggability 0.78

Structure

x-ray diffraction · 1 distinct chain · 49% helix, 13% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	PDX1 C-terminal-inhibiting factor 1	protein	468	49% helix, 13% strand	A0A0R4IKJ1

Ligands and binding sites

SAH · S-adenosyl-L-homocysteine · ligand · chains A
EDO · 1,2-ethanediol · additive · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	723	0.78	0.82	83	SAH, EDO
2	265	0.54	0.76	31	empty
3	56	0.26	0.73	12	empty

Compared structures

6IRY · Crystal structure of the zebrafish cap-specific adenosine methyltransferase bound to SAH · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A0A0R4IKJ1
Elsewhere: RCSB PDB 6IRY · PDBe 6IRY · UniProt A0A0R4IKJ1

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