MolNFT v1 · #152743 · protein

Crystal structure of the human cap-specific adenosine methyltransferase

6IRV · Phosphorylated ctd-interacting factor 1: “Crystal structure of the human cap-specific adenosine methyltransferase”. X-ray diffraction, 11 pockets (best druggability 0.84). MolNFT v1 #152743 on GenesisL1: 3D structure, binding sites…

PDB: 6IRV
Type: protein
Length: 988 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Phosphorylated ctd-interacting factor 1
UniProt: Q9H4Z3
Pockets: 11 · best druggability 0.84

Structure

x-ray diffraction · 1 distinct chain · 47% helix, 13% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Phosphorylated ctd-interacting factor 1	protein	494	47% helix, 13% strand	Q9H4Z3

Pockets

11 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	758	0.84	0.87	102	empty
2	466	0.81	0.88	62	empty
3	389	0.68	0.81	45	empty
4	56	0.60	0.92	19	empty
5	124	0.54	0.82	24	empty

Interfaces

1 interface between chains.

A–B · 1339 Å² buried · 8 hydrogen bonds · protein-protein

Compared structures

6IRV · Crystal structure of the human cap-specific adenosine methyltransferase · the same entry in another collection · chain A against A, TM-score 1.00
Q9H4Z3 · AlphaFold monomer V2.0 prediction for mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase… · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9H4Z3
Elsewhere: RCSB PDB 6IRV · PDBe 6IRV · UniProt Q9H4Z3

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