MolNFT v1 · #152739 · protein
Solution structure of DISC1/ATF4 complex
6IRR · Disrupted in schizophrenia 1 HOMOLOG,CYCLIC AMP-dependent…: “Solution structure of DISC1/ATF4 complex”. Solution nmr, 2 pockets (best druggability 0.55). MolNFT v1 #152739 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 6IRR
- Type
- protein
- Length
- 133 residues
- Chains
- 1
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Disrupted in schizophrenia 1 HOMOLOG,CYCLIC AMP-dependent transcription factor atf-4
- UniProt
- Q811T9, Q06507
- Pockets
- 2 · best druggability 0.55
Structure
solution nmr · 1 distinct chain · 56% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Disrupted in schizophrenia 1 HOMOLOG,CYCLIC AMP-dependent transcription factor atf-4 | protein | 133 | 56% helix, 0% strand | Q811T9, Q06507 |
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 63 | 0.55 | 0.87 | 15 | empty |
| 2 | 107 | 0.55 | 0.83 | 18 | empty |
Compared structures
- 6IRR · Solution structure of DISC1/ATF4 complex · the same entry in another collection · chain A against A, TM-score 1.00
- Q811T9 · AlphaFold monomer V2.0 prediction for disrupted in schizophrenia 1 homolog (Q811T9) · a predicted model of the same protein · chain A against A, TM-score 0.56
- Q06507 · AlphaFold monomer V2.0 prediction for cyclic AMP-dependent transcription factor atf-4… · a predicted model of the same protein · chain A against A, TM-score 0.29
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q811T9
- Every structure of UniProt Q06507
- Elsewhere: RCSB PDB 6IRR · PDBe 6IRR · UniProt Q811T9 · UniProt Q06507
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