MolNFT v1 · #152727 · protein
Complex structure of inadl PDZ89 and PLCB4 C-terminal cc-pbm
6IRD · 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase: “Complex structure of inadl PDZ89 and PLCB4 C-terminal cc-pbm”. X-ray diffraction, 1 ligand (AU), 2 pockets (best druggability 0.68). MolNFT v1 #152727 on GenesisL1: 3D…
- PDB
- 6IRD
- Type
- protein
- Length
- 434 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; Inad-like protein
- EC
- 3.1.4.11
- UniProt
- Q91UZ1, Q8NI35
- Ligands
- AU
- Pockets
- 2 · best druggability 0.68
Structure
x-ray diffraction · 2 distinct chains · 60% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase (EC 3.1.4.11) | protein | 254 | 92% helix, 1% strand | Q91UZ1 |
| C | Inad-like protein | protein | 180 | 16% helix, 32% strand | Q8NI35 |
Ligands and binding sites
- AU · Gold ion · metal · 5 copies · chains B, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 599 | 0.68 | 0.77 | 56 | empty |
| 2 | 52 | 0.36 | 0.79 | 17 | empty |
Interfaces
1 interface between chains.
- B–C · 1336 Ų buried · 19 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q91UZ1
- Every structure of UniProt Q8NI35
- Elsewhere: RCSB PDB 6IRD · PDBe 6IRD · UniProt Q91UZ1 · UniProt Q8NI35
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