MolNFT v1 · #15258 · protein

Crystal structure of human pro-granzyme K

1MZA: “Crystal structure of human pro-granzyme K”. X-ray diffraction, 2 pockets (best druggability 0.35). MolNFT v1 #15258 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1MZA
Type: protein
Length: 240 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Pro-granzyme K
EC: 3.4.21.-
UniProt: P49863
Pockets: 2 · best druggability 0.35

Structure

x-ray diffraction · 1 distinct chain · 7% helix, 33% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Pro-granzyme K (EC 3.4.21.-)	protein	240	7% helix, 33% strand	P49863

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	106	0.35	0.73	24	empty
2	62	0.32	0.76	15	empty

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

1MZA · crystal structure of human pro-granzyme K · the same entry in another collection · chain A against A, TM-score 1.00
P49863 · AlphaFold monomer V2.0 prediction for granzyme K (P49863) · a predicted model of the same protein · chain A against A, TM-score 0.93

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P49863
Elsewhere: RCSB PDB 1MZA · PDBe 1MZA · UniProt P49863

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