MolNFT v1 · #152527 · protein

Crystal structure of the GAS7 F-bar domain

6IKN · Growth arrest-specific protein 7: “Crystal structure of the GAS7 F-bar domain”. X-ray diffraction, 6 pockets (best druggability 0.60). MolNFT v1 #152527 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6IKN
Type: protein
Length: 1,217 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Growth arrest-specific protein 7
Pockets: 6 · best druggability 0.60

Structure

x-ray diffraction · 2 distinct chains · 72% helix, 4% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Growth arrest-specific protein 7	protein	305	72% helix, 4% strand	—
B, C, D	Growth arrest-specific protein 7	protein	304	73% helix, 4% strand	—

Pockets

6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	500	0.60	0.74	49	empty
2	74	0.59	0.89	21	empty
3	61	0.53	0.87	22	empty
4	155	0.44	0.76	16	empty
5	76	0.36	0.76	16	empty

Interfaces

4 interfaces between chains.

C–D · 5390 Å² buried · 68 hydrogen bonds · protein-protein
A–B · 5311 Å² buried · 60 hydrogen bonds · protein-protein
B–D · 353 Å² buried · 2 hydrogen bonds · protein-protein
A–D · 271 Å² buried · 3 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 44 modified (engineered).

Compared structures

6IKN · Crystal structure of the GAS7 F-BAR domain · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 6IKN · PDBe 6IKN

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