MolNFT v1 · #152441 · protein
Crystal structure of drosophila NXF1 NTF2 domain in complex with NXT1/P15
6IHJ · Nuclear RNA export factor 1: “Crystal structure of drosophila NXF1 NTF2 domain in complex with NXT1/P15”. X-ray diffraction, 11 pockets (best druggability 0.63). MolNFT v1 #152441 on GenesisL1: 3D structure, binding sites and…
- PDB
- 6IHJ
- Type
- protein
- Length
- 591 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Nuclear RNA export factor 1; NTF2-related export protein
- UniProt
- Q9U1H9, Q9V3H8
- Pockets
- 11 · best druggability 0.63
Structure
x-ray diffraction · 4 distinct chains · 30% helix, 41% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Nuclear RNA export factor 1 | protein | 173 | 27% helix, 35% strand | Q9U1H9 |
| C | Nuclear RNA export factor 1 | protein | 168 | 28% helix, 38% strand | Q9U1H9 |
| B | NTF2-related export protein | protein | 128 | 34% helix, 48% strand | Q9V3H8 |
| D | NTF2-related export protein | protein | 122 | 30% helix, 48% strand | Q9V3H8 |
Pockets
11 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 346 | 0.63 | 0.79 | 38 | empty |
| 2 | 492 | 0.62 | 0.76 | 51 | empty |
| 3 | 86 | 0.40 | 0.78 | 20 | empty |
| 4 | 109 | 0.39 | 0.76 | 17 | empty |
| 5 | 62 | 0.39 | 0.79 | 20 | empty |
Interfaces
3 interfaces between chains.
- A–B · 2058 Ų buried · 33 hydrogen bonds · protein-protein
- C–D · 1503 Ų buried · 23 hydrogen bonds · protein-protein
- A–C · 374 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
- 6IHJ · Crystal structure of Drosophila Nxf1 NTF2 domain in complex with Nxt1/p15 · the same entry in another collection · chain D against D, TM-score 1.00
- Q9V3H8 · AlphaFold monomer V2.0 prediction for NTF2-related export protein (Q9V3H8) · a predicted model of the same protein · chain B against A, TM-score 0.97
- Q9U1H9 · AlphaFold monomer V2.0 prediction for nuclear RNA export factor 1 (Q9U1H9) · a predicted model of the same protein · chain A against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9U1H9
- Every structure of UniProt Q9V3H8
- Elsewhere: RCSB PDB 6IHJ · PDBe 6IHJ · UniProt Q9U1H9 · UniProt Q9V3H8
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