MolNFT v1 · #152416 · protein
MPZL1 mutant - V145G, Q146K, P147T and G148S
6IGT · Myelin protein zero-like protein 1: “MPZL1 mutant - V145G, Q146K, P147T and G148S”. X-ray diffraction, 4 pockets (best druggability 0.65). MolNFT v1 #152416 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6IGT
- Type
- protein
- Length
- 466 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Myelin protein zero-like protein 1
- UniProt
- O95297
- Pockets
- 4 · best druggability 0.65
Structure
x-ray diffraction · 2 distinct chains · 6% helix, 51% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Myelin protein zero-like protein 1 | protein | 117 | 8% helix, 51% strand | O95297 |
| C, D | Myelin protein zero-like protein 1 | protein | 116 | 5% helix, 51% strand | O95297 |
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 267 | 0.65 | 0.82 | 45 | empty |
| 2 | 235 | 0.63 | 0.82 | 33 | empty |
| 3 | 122 | 0.46 | 0.78 | 27 | empty |
| 4 | 123 | 0.45 | 0.77 | 23 | empty |
Interfaces
3 interfaces between chains.
- B–C · 586 Ų buried · 7 hydrogen bonds · protein-protein
- A–D · 567 Ų buried · 7 hydrogen bonds · protein-protein
- C–D · 458 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O95297
- Elsewhere: RCSB PDB 6IGT · PDBe 6IGT · UniProt O95297
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