MolNFT v1 · #152383 · protein + RNA
Cryo-EM structure of type III-a csm-CTR2-dsdna complex
6IFU · Type III-a CRISPR-associated protein CSM1: “Cryo-EM structure of type III-a csm-CTR2-dsdna complex”. Electron microscopy, 20 pockets (best druggability 0.88). MolNFT v1 #152383 on GenesisL1: 3D structure, binding sites and pockets…
- PDB
- 6IFU
- Type
- protein + RNA
- Length
- 2,263 residues
- Chains
- 10
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Type III-a CRISPR-associated protein CSM1; Type III-a CRISPR-associated protein CSM2…
- UniProt
- A0A2U2M0F3, A0A2U2M049, A0A2U2M035, A0A2U2M037, A0A2U2M038
- Pockets
- 20 · best druggability 0.88
Structure
electron microscopy · 9 distinct chains · 31% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Type III-a CRISPR-associated protein CSM1 | protein | 706 | 44% helix, 9% strand | A0A2U2M0F3 |
| B, C | Type III-a CRISPR-associated protein CSM2 | protein | 121 | 66% helix, 2% strand | A0A2U2M049 |
| D | Type III-a CRISPR-associated ramp protein CSM3 | protein | 217 | 16% helix, 26% strand | A0A2U2M035 |
| E | Type III-a CRISPR-associated ramp protein CSM3 | protein | 216 | 25% helix, 29% strand | A0A2U2M035 |
| F | Type III-a CRISPR-associated ramp protein CSM3 | protein | 207 | 21% helix, 25% strand | A0A2U2M035 |
| G | Type III-a CRISPR-associated ramp protein CSM4 | protein | 272 | 17% helix, 18% strand | A0A2U2M037 |
| H | Type III-a CRISPR-associated ramp protein CSM5 | protein | 341 | 23% helix, 21% strand | A0A2U2M038 |
| I | Crrna | rna | 34 | — | — |
| J | CTR2 | rna | 28 | — | — |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 933 | 0.88 | 0.90 | 112 | empty |
| 2 | 403 | 0.84 | 0.93 | 43 | empty |
| 3 | 201 | 0.81 | 0.96 | 38 | empty |
| 4 | 782 | 0.81 | 0.84 | 77 | empty |
| 5 | 143 | 0.77 | 0.95 | 28 | empty |
Interfaces
35 interfaces between chains.
- G–I · 1572 Ų buried · 44 hydrogen bonds · protein-nucleic
- F–G · 1491 Ų buried · 13 hydrogen bonds · protein-protein
- D–H · 1487 Ų buried · 20 hydrogen bonds · protein-protein
- E–F · 1430 Ų buried · 15 hydrogen bonds · protein-protein
- D–E · 1415 Ų buried · 10 hydrogen bonds · protein-protein
Compared structures
- 6IFU · Cryo-EM structure of type III-A Csm-CTR2-dsDNA complex · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A2U2M0F3
- Every structure of UniProt A0A2U2M049
- Every structure of UniProt A0A2U2M035
- Every structure of UniProt A0A2U2M037
- Every structure of UniProt A0A2U2M038
- Elsewhere: RCSB PDB 6IFU · PDBe 6IFU · UniProt A0A2U2M0F3 · UniProt A0A2U2M049 · UniProt A0A2U2M035 · UniProt A0A2U2M037 · UniProt A0A2U2M038
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