MolNFT v1 · #152347 · protein
The structure of TRIM66 phd-bromo domain with unmodified H3 N terminal peptide
6IEU · Tripartite motif-containing protein 66: “The structure of TRIM66 phd-bromo domain with unmodified H3 N terminal peptide”. X-ray diffraction, 1 ligand (ZN), 1 pocket (best druggability 0.45). MolNFT v1 #152347 on GenesisL1: 3D…
- PDB
- 6IEU
- Type
- protein
- Length
- 180 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tripartite motif-containing protein 66; Ala-arg-thr-lys-gln-thr-ala-arg-lys-ser-thr-gly
- UniProt
- O15016
- Ligands
- ZN
- Pockets
- 1 · best druggability 0.45
Structure
x-ray diffraction · 2 distinct chains · 41% helix, 5% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tripartite motif-containing protein 66 | protein | 170 | 44% helix, 4% strand | O15016 |
| C | Ala-arg-thr-lys-gln-thr-ala-arg-lys-ser-thr-gly | protein | 10 | 0% helix, 30% strand | — |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 60 | 0.45 | 0.83 | 18 | empty |
Interfaces
1 interface between chains.
- A–C · 718 Ų buried · 26 hydrogen bonds · protein-protein
Compared structures
- 6IEU · The structure of TRIM66 PHD-Bromo domain with unmodified H3 N terminal peptide · the same entry in another collection · chain A against A, TM-score 1.00
- O15016 · AlphaFold monomer V2.0 prediction for tripartite motif-containing protein 66 (O15016) · a predicted model of the same protein · chain A against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O15016
- Elsewhere: RCSB PDB 6IEU · PDBe 6IEU · UniProt O15016
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.