MolNFT v1 · #152331 · protein
Structure of rvfv gn and human monoclonal antibody R15
6IEB · R15 H chain: “Structure of rvfv gn and human monoclonal antibody R15”. X-ray diffraction, 20 pockets (best druggability 0.58). MolNFT v1 #152331 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6IEB
- Type
- protein
- Length
- 1,392 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- R15 H chain; R15 L chain; Nsmgngc
- UniProt
- H9BSP3
- Pockets
- 20 · best druggability 0.58
Structure
x-ray diffraction · 6 distinct chains · 9% helix, 41% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| H | R15 H chain | protein | 211 | 8% helix, 49% strand | — |
| L | R15 L chain | protein | 207 | 8% helix, 49% strand | — |
| B | Nsmgngc | protein | 293 | 12% helix, 30% strand | H9BSP3 |
| A | Nsmgngc | protein | 295 | 11% helix, 30% strand | H9BSP3 |
| E | R15 H chain | protein | 182 | 3% helix, 51% strand | — |
| F | R15 L chain | protein | 204 | 6% helix, 48% strand | — |
Pockets
20 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 458 | 0.58 | 0.74 | 58 | empty |
| 2 | 452 | 0.57 | 0.74 | 50 | empty |
| 3 | 63 | 0.56 | 0.88 | 17 | empty |
| 4 | 233 | 0.53 | 0.76 | 36 | empty |
| 5 | 128 | 0.52 | 0.81 | 20 | empty |
Interfaces
8 interfaces between chains.
- H–L · 1497 Ų buried · 16 hydrogen bonds · protein-protein
- E–F · 1319 Ų buried · 15 hydrogen bonds · protein-protein
- H–A · 493 Ų buried · 4 hydrogen bonds · protein-protein
- B–E · 437 Ų buried · 4 hydrogen bonds · protein-protein
- B–F · 314 Ų buried · 6 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 28 disulfide (disulfide).
Compared structures
- 6IEB · Structure of RVFV Gn and human monoclonal antibody R15 · the same entry in another collection · chain H against H, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt H9BSP3
- Elsewhere: RCSB PDB 6IEB · PDBe 6IEB · UniProt H9BSP3
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