MolNFT v1 · #152214 · protein
Structure of human NKP46 in complex with antibody NKP46-1 and NKP46-4
6IAS · Fab NKP46-1 heavy chain: “Structure of human NKP46 in complex with antibody NKP46-1 and NKP46-4”. X-ray diffraction, 3 pockets (best druggability 0.63). MolNFT v1 #152214 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6IAS
- Type
- protein
- Length
- 428 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Fab NKP46-1 heavy chain; Fab NKP46-1 light chain
- Pockets
- 3 · best druggability 0.63
Structure
x-ray diffraction · 2 distinct chains · 7% helix, 52% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| H | Fab NKP46-1 heavy chain | protein | 217 | 7% helix, 52% strand | — |
| L | Fab NKP46-1 light chain | protein | 211 | 6% helix, 52% strand | — |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 589 | 0.63 | 0.74 | 63 | empty |
| 2 | 58 | 0.34 | 0.78 | 14 | empty |
| 3 | 69 | 0.31 | 0.75 | 18 | empty |
Interfaces
1 interface between chains.
- H–L · 1792 Ų buried · 15 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 6IAS · structure of human NKp46 in complex with antibody NKp46-1 and NKp46-4 · the same entry in another collection · chain H against H, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 6IAS · PDBe 6IAS
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