MolNFT v1 · #152179 · protein

HROBO2 extracellular domains 2-3

6I9S · Roundabout homolog 2: “HROBO2 extracellular domains 2-3”. X-ray diffraction, 1 ligand (NA), 1 pocket (best druggability 0.45). MolNFT v1 #152179 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6I9S
Type: protein
Length: 371 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Roundabout homolog 2
UniProt: Q9HCK4
Ligands: NA
Pockets: 1 · best druggability 0.45

Structure

x-ray diffraction · 2 distinct chains · 2% helix, 50% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Roundabout homolog 2	protein	187	3% helix, 54% strand	Q9HCK4
B	Roundabout homolog 2	protein	184	2% helix, 46% strand	Q9HCK4

Ligands and binding sites

NA · Sodium ion · metal · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	127	0.45	0.78	31	empty

Interfaces

1 interface between chains.

A–B · 632 Å² buried · 6 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

6I9S · hRobo2 Extracellular Domains 2-3 · the same entry in another collection · chain B against B, TM-score 1.00
Q9HCK4 · AlphaFold monomer V2.0 prediction for roundabout homolog 2 (Q9HCK4) · a predicted model of the same protein · chain A against A, TM-score 0.94

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9HCK4
Elsewhere: RCSB PDB 6I9S · PDBe 6I9S · UniProt Q9HCK4

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