MolNFT v1 · #152134 · protein
Structure of the plant immune signaling node EDS1 (enhanced disease susceptibility 1) in complex with nanobody ENB15
6I8H · Protein EDS1L: “Structure of the plant immune signaling node EDS1 (enhanced disease susceptibility 1) in complex with…”. X-ray diffraction, 10 pockets (best druggability 0.71). MolNFT v1 #152134 on GenesisL1: 3D structure, binding…
- PDB
- 6I8H
- Type
- protein
- Length
- 734 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein EDS1L; EDS1-specific nanobody
- UniProt
- Q9XF23
- Pockets
- 10 · best druggability 0.71
Structure
x-ray diffraction · 2 distinct chains · 51% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein EDS1L | protein | 618 | 60% helix, 9% strand | Q9XF23 |
| B | EDS1-specific nanobody | protein | 116 | 3% helix, 42% strand | — |
Pockets
10 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 710 | 0.71 | 0.78 | 71 | empty |
| 2 | 323 | 0.65 | 0.81 | 38 | empty |
| 3 | 165 | 0.50 | 0.78 | 26 | empty |
| 4 | 71 | 0.42 | 0.80 | 18 | empty |
| 5 | 168 | 0.40 | 0.72 | 27 | empty |
Interfaces
1 interface between chains.
- A–B · 834 Ų buried · 8 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 6I8H · Structure of the plant immune signaling node EDS1 (enhanced disease susceptibility 1) in… · the same entry in another collection · chain A against A, TM-score 1.00
- Q9XF23 · AlphaFold monomer V2.0 prediction for protein EDS1L (Q9XF23) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9XF23
- Elsewhere: RCSB PDB 6I8H · PDBe 6I8H · UniProt Q9XF23
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