MolNFT v1 · #152077 · protein
Circular permutant of ribosomal protein S6, adding 9AA to C terminal of P68-69, L75A mutant
6I6S · 30S ribosomal protein S6,30S ribosomal protein S6,30S…: “Circular permutant of ribosomal protein S6, adding 9AA to C terminal of P68-69, L75A mutant”. X-ray diffraction, 2 ligands (K, NA), 2 pockets (best druggability 0.52). MolNFT…
- PDB
- 6I6S
- Type
- protein
- Length
- 192 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 30S ribosomal protein S6,30S ribosomal protein S6,30S ribosomal protein S6,30S ribosomal…
- UniProt
- Q5SLP8
- Ligands
- K, NA
- Pockets
- 2 · best druggability 0.52
Structure
x-ray diffraction · 2 distinct chains · 29% helix, 40% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | 30S ribosomal protein S6,30S ribosomal protein S6,30S ribosomal protein S6,30S ribosomal protein S6,30S ribosomal protein S6,30S ribosomal protein S6,30S ribosomal protein S6,30S ribosomal protein S6 | protein | 96 | 27% helix, 40% strand | Q5SLP8 |
| B | 30S ribosomal protein S6,30S ribosomal protein S6,30S ribosomal protein S6,30S ribosomal protein S6,30S ribosomal protein S6,30S ribosomal protein S6,30S ribosomal protein S6,30S ribosomal protein S6 | protein | 96 | 30% helix, 40% strand | Q5SLP8 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 85 | 0.52 | 0.84 | 18 | empty |
| 2 | 135 | 0.43 | 0.76 | 23 | empty |
Interfaces
1 interface between chains.
- A–B · 364 Ų buried · 5 hydrogen bonds · protein-protein
Compared structures
- 6I6S · Circular permutant of ribosomal protein S6, adding 9aa to C terminal of P68-69, L75A… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q5SLP8
- Elsewhere: RCSB PDB 6I6S · PDBe 6I6S · UniProt Q5SLP8
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