MolNFT v1 · #151977 · protein
Crystal structure of deah-box ATPase PRP22
6I3O · Putative pre-mRNA splicing factor: “Crystal structure of deah-box ATPase PRP22”. X-ray diffraction, 17 pockets (best druggability 0.75). MolNFT v1 #151977 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6I3O
- Type
- protein
- Length
- 1,166 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Putative pre-mRNA splicing factor
- UniProt
- G0S700
- Pockets
- 17 · best druggability 0.75
Structure
x-ray diffraction · 2 distinct chains · 45% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Putative pre-mRNA splicing factor | protein | 589 | 44% helix, 19% strand | G0S700 |
| B | Putative pre-mRNA splicing factor | protein | 577 | 45% helix, 18% strand | G0S700 |
Pockets
17 pockets found on a 1 Å grid, 9 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 581 | 0.75 | 0.82 | 59 | empty |
| 2 | 1111 | 0.75 | 0.78 | 118 | empty |
| 3 | 228 | 0.65 | 0.84 | 28 | empty |
| 4 | 671 | 0.65 | 0.75 | 60 | empty |
| 5 | 216 | 0.60 | 0.81 | 31 | empty |
Interfaces
1 interface between chains.
- A–B · 1100 Ų buried · 6 hydrogen bonds · protein-protein
Compared structures
- 6I3O · Crystal structure of DEAH-box ATPase Prp22 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt G0S700
- Elsewhere: RCSB PDB 6I3O · PDBe 6I3O · UniProt G0S700
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