MolNFT v1 · #151942 · protein + RNA
Helical RNA-bound hantaan virus nucleocapsid
6I2N · RNA (5'-R(P*UP*UP*U)-3'): “Helical RNA-bound hantaan virus nucleocapsid”. Electron microscopy, 5 pockets (best druggability 0.71). MolNFT v1 #151942 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6I2N
- Type
- protein + RNA
- Length
- 339 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- RNA (5'-R(P*UP*UP*U)-3'); Nucleoprotein
- UniProt
- P05133
- Pockets
- 5 · best druggability 0.71
Structure
electron microscopy · 2 distinct chains · 49% helix, 5% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| U | RNA (5'-R(P*UP*UP*U)-3') | rna | 3 | — | — |
| D | Nucleoprotein | protein | 336 | 49% helix, 5% strand | P05133 |
Pockets
5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 294 | 0.71 | 0.85 | 39 | empty |
| 2 | 160 | 0.47 | 0.77 | 30 | empty |
| 3 | 74 | 0.39 | 0.78 | 13 | empty |
| 4 | 120 | 0.38 | 0.74 | 18 | empty |
| 5 | 52 | 0.27 | 0.74 | 14 | empty |
Interfaces
1 interface between chains.
- U–D · 464 Ų buried · 8 hydrogen bonds · protein-nucleic
Compared structures
- 6I2N · Helical RNA-bound Hantaan virus nucleocapsid · the same entry in another collection · chain U against U, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P05133
- Elsewhere: RCSB PDB 6I2N · PDBe 6I2N · UniProt P05133
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