MolNFT v1 · #151879 · protein + RNA
Crystal structure of dmtailor in complex with U6 RNA
6I0U · Terminal uridylyltransferase tailor: “Crystal structure of dmtailor in complex with U6 RNA”. X-ray diffraction, 1 ligand (MG), 3 pockets (best druggability 0.55). MolNFT v1 #151879 on GenesisL1: 3D structure, binding sites and…
- PDB
- 6I0U
- Type
- protein + RNA
- Length
- 354 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Terminal uridylyltransferase tailor; RNA (5'-R(*UP*UP*UP*U)-3')
- EC
- 2.7.7.52
- UniProt
- Q9VI58
- Ligands
- MG
- Pockets
- 3 · best druggability 0.55
Structure
x-ray diffraction · 2 distinct chains · 43% helix, 12% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Terminal uridylyltransferase tailor (EC 2.7.7.52) | protein | 350 | 43% helix, 12% strand | Q9VI58 |
| B | RNA (5'-R(*UP*UP*UP*U)-3') | rna | 4 | — | — |
Ligands and binding sites
- MG · Magnesium ion · metal · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 201 | 0.55 | 0.80 | 33 | empty |
| 2 | 113 | 0.38 | 0.74 | 19 | empty |
| 3 | 53 | 0.32 | 0.77 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 572 Ų buried · 17 hydrogen bonds · protein-nucleic
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9VI58
- Elsewhere: RCSB PDB 6I0U · PDBe 6I0U · UniProt Q9VI58
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