MolNFT v1 · #151877 · protein
Crystal structure of dmtailor in complex with umpnpp
6I0S · Terminal uridylyltransferase tailor: “Crystal structure of dmtailor in complex with umpnpp”. X-ray diffraction, 2 ligands (2KH, MG), 2 pockets (best druggability 0.70). MolNFT v1 #151877 on GenesisL1: 3D structure, binding sites and…
- PDB
- 6I0S
- Type
- protein
- Length
- 345 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Terminal uridylyltransferase tailor
- EC
- 2.7.7.52
- UniProt
- Q9VI58
- Ligands
- 2KH, MG
- Pockets
- 2 · best druggability 0.70
Structure
x-ray diffraction · 1 distinct chain · 46% helix, 12% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Terminal uridylyltransferase tailor (EC 2.7.7.52) | protein | 345 | 46% helix, 12% strand | Q9VI58 |
Ligands and binding sites
- 2KH · 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]uridine · ligand · chains A
- MG · Magnesium ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 549 | 0.70 | 0.79 | 45 | 2KH, MG |
| 2 | 129 | 0.62 | 0.86 | 31 | empty |
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9VI58
- Elsewhere: RCSB PDB 6I0S · PDBe 6I0S · UniProt Q9VI58
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