MolNFT v1 · #151838 · protein

Apo structure of tp domain from clinical penicillin-resistant mutant neisseria gonorrhoea strain 6140 penicillin-binding protein 2 (PBP2)

6HZJ · Probable peptidoglycan D,D-transpeptidase pena: “Apo structure of tp domain from clinical penicillin-resistant mutant neisseria gonorrhoea strain 6140…”. X-ray diffraction, 9 pockets (best druggability 0.63). MolNFT v1 #151838 on…

PDB: 6HZJ
Type: protein
Length: 653 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Probable peptidoglycan D,D-transpeptidase pena
EC: 3.4.16.4
UniProt: E5KLA8
Pockets: 9 · best druggability 0.63

Structure

x-ray diffraction · 2 distinct chains · 36% helix, 22% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Probable peptidoglycan D,D-transpeptidase pena (EC 3.4.16.4)	protein	326	36% helix, 21% strand	E5KLA8
B	Probable peptidoglycan D,D-transpeptidase pena (EC 3.4.16.4)	protein	327	36% helix, 22% strand	E5KLA8

Pockets

9 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	361	0.63	0.78	27	empty
2	127	0.57	0.84	23	empty
3	110	0.55	0.84	23	empty
4	270	0.53	0.75	33	empty
5	225	0.49	0.75	34	empty

Interfaces

1 interface between chains.

A–B · 908 Å² buried · 22 hydrogen bonds · protein-protein

Compared structures

6HZJ · Apo structure of TP domain from clinical penicillin-resistant mutant Neisseria gonorrhoea… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt E5KLA8
Elsewhere: RCSB PDB 6HZJ · PDBe 6HZJ · UniProt E5KLA8

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.