MolNFT v1 · #151801 · protein

Regulatory subunit of a camp-independent protein kinase a from trypanosoma cruzi at 1.4 a resolution in complex with inosine

6HYI · Protein kinase a regulatory subunit: “Regulatory subunit of a camp-independent protein kinase a from trypanosoma cruzi at 1.4 a resolution in…”. X-ray diffraction, 1 ligand (NOS), 4 pockets (best druggability 0.75). MolNFT v1…

PDB: 6HYI
Type: protein
Length: 289 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Protein kinase a regulatory subunit
UniProt: Q86RB0
Ligands: NOS
Pockets: 4 · best druggability 0.75

Structure

x-ray diffraction · 1 distinct chain · 36% helix, 29% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
B	Protein kinase a regulatory subunit	protein	289	36% helix, 29% strand	Q86RB0

Ligands and binding sites

NOS · Inosine · ligand · 2 copies · chains B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	88	0.75	0.97	19	NOS
2	112	0.59	0.85	22	NOS
3	103	0.40	0.76	18	empty
4	55	0.28	0.74	14	empty

Compared structures

6HYI · Regulatory subunit of a cAMP-independent protein kinase A from Trypanosoma cruzi at 1.4 A… · the same entry in another collection · chain B against B, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q86RB0
Elsewhere: RCSB PDB 6HYI · PDBe 6HYI · UniProt Q86RB0

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