MolNFT v1 · #151798 · protein
Crystal structure of the third fniii domain from rat BETA4 integrin, a binding site for periaxin
6HYF · Integrin beta-4: “Crystal structure of the third fniii domain from rat BETA4 integrin, a binding site for periaxin”. X-ray diffraction, 4 pockets (best druggability 0.54). MolNFT v1 #151798 on GenesisL1: 3D structure, binding sites…
- PDB
- 6HYF
- Type
- protein
- Length
- 379 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Integrin beta-4
- UniProt
- Q64632
- Pockets
- 4 · best druggability 0.54
Structure
x-ray diffraction · 4 distinct chains · 0% helix, 49% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Integrin beta-4 | protein | 106 | 0% helix, 44% strand | Q64632 |
| B | Integrin beta-4 | protein | 100 | 0% helix, 50% strand | Q64632 |
| C | Integrin beta-4 | protein | 91 | 0% helix, 52% strand | Q64632 |
| D | Integrin beta-4 | protein | 82 | 0% helix, 51% strand | Q64632 |
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 53 | 0.54 | 0.89 | 19 | empty |
| 2 | 171 | 0.44 | 0.75 | 27 | empty |
| 3 | 128 | 0.44 | 0.77 | 27 | empty |
| 4 | 91 | 0.39 | 0.77 | 29 | empty |
Interfaces
3 interfaces between chains.
- A–B · 928 Ų buried · 15 hydrogen bonds · protein-protein
- B–C · 548 Ų buried · 11 hydrogen bonds · protein-protein
- C–D · 488 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
- 6HYF · Crystal structure of the third FNIII domain from rat beta4 integrin, a binding site for… · the same entry in another collection · chain D against D, TM-score 1.00
- Q64632 · AlphaFold monomer V2.0 prediction for integrin beta-4 (Q64632) · a predicted model of the same protein · chain C against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q64632
- Elsewhere: RCSB PDB 6HYF · PDBe 6HYF · UniProt Q64632
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.