MolNFT v1 · #151785 · protein
Structure guided design of an antibacterial peptide that targets udp- N-acetylglucosamine acyltransferase
6HY2 · Acyl-[acyl-carrier-protein]--udp-N-acetylglucosamine O…: “Structure guided design of an antibacterial peptide that targets udp- N-acetylglucosamine acyltransferase”. X-ray diffraction, 2 pockets (best druggability 0.29). MolNFT v1…
- PDB
- 6HY2
- Type
- protein
- Length
- 274 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Acyl-[acyl-carrier-protein]--udp-N-acetylglucosamine O- acyltransferase…
- EC
- 2.3.1.129
- UniProt
- P0A722
- Pockets
- 2 · best druggability 0.29
Structure
x-ray diffraction · 2 distinct chains · 16% helix, 30% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| X | Acyl-[acyl-carrier-protein]--udp-N-acetylglucosamine O- acyltransferase (EC 2.3.1.129) | protein | 262 | 17% helix, 30% strand | P0A722 |
| A | TRP-met-leu-asp-pro-ile-ala-gly-lys-TRP-ser-arg | protein | 12 | 0% helix, 33% strand | — |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 63 | 0.29 | 0.74 | 13 | empty |
| 2 | 53 | 0.29 | 0.74 | 17 | empty |
Interfaces
1 interface between chains.
- X–A · 467 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 6HY2 · Structure guided design of an antibacterial peptide that targets UDP-N-acetylglucosamine… · the same entry in another collection · chain X against X, TM-score 1.00
- P0A722 · AlphaFold monomer V2.0 prediction for acyl-[acyl-carrier… · a predicted model of the same protein · chain X against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0A722
- Elsewhere: RCSB PDB 6HY2 · PDBe 6HY2 · UniProt P0A722
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