MolNFT v1 · #15176 · protein

Parm from plasmid R1 apo form

1MWK: “Parm from plasmid R1 apo form”. X-ray diffraction, 3 pockets (best druggability 0.67). MolNFT v1 #15176 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1MWK
Type: protein
Length: 634 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Parm
UniProt: P11904
Pockets: 3 · best druggability 0.67

Structure

x-ray diffraction · 2 distinct chains · 39% helix, 25% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Parm	protein	320	39% helix, 24% strand	P11904
B	Parm	protein	314	39% helix, 25% strand	P11904

Pockets

3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	487	0.67	0.78	40	empty
2	432	0.64	0.78	38	empty
3	73	0.30	0.73	18	empty

Interfaces

1 interface between chains.

A–B · 360 Å² buried · 3 hydrogen bonds · protein-protein

Compared structures

1MWK · ParM from plasmid R1 APO form · the same entry in another collection · chain A against A, TM-score 1.00
P11904 · AlphaFold monomer V2.0 prediction for plasmid segregation protein parm (P11904) · a predicted model of the same protein · chain B against A, TM-score 0.77

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P11904
Elsewhere: RCSB PDB 1MWK · PDBe 1MWK · UniProt P11904

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