MolNFT v1 · #151747 · protein

Mature mlv capsid hexamer structure in intact virus particles

6HWX · Putative gag polyprotein: “Mature mlv capsid hexamer structure in intact virus particles”. Electron microscopy, 5 pockets (best druggability 0.80). MolNFT v1 #151747 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6HWX
Type: protein
Length: 708 residues
Chains: 3
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Putative gag polyprotein
UniProt: A0A240FAQ8
Pockets: 5 · best druggability 0.80

Structure

electron microscopy · 1 distinct chain · 60% helix, 3% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C	Putative gag polyprotein	protein	236	60% helix, 3% strand	A0A240FAQ8

Pockets

5 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1011	0.80	0.82	117	empty
2	526	0.72	0.81	73	empty
3	683	0.70	0.77	69	empty
4	386	0.68	0.81	57	empty
5	327	0.60	0.78	54	empty

Interfaces

3 interfaces between chains.

A–B · 399 Å² buried · 3 hydrogen bonds · protein-protein
B–C · 214 Å² buried · 0 hydrogen bonds · protein-protein
A–C · 49 Å² buried · 1 hydrogen bond · protein-protein

Compared structures

6HWX · Mature MLV capsid hexamer structure in intact virus particles · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A0A240FAQ8
Elsewhere: RCSB PDB 6HWX · PDBe 6HWX · UniProt A0A240FAQ8

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