MolNFT v1 · #15174 · protein + DNA
Crystal structure of a mug-DNA product complex
1MWI · 5'-D(*CP*GP*CP*GP*AP*GP*(AAB)P*TP*CP*GP*CP*G)-3': “Crystal structure of a mug-DNA product complex”. X-ray diffraction, 1 pocket (best druggability 0.66). MolNFT v1 #15174 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1MWI
- Type
- protein + DNA
- Length
- 177 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 5'-D(*CP*GP*CP*GP*AP*GP*(AAB)P*TP*CP*GP*CP*G)-3'; G/U mismatch-specific DNA glycosylase
- EC
- 3.2.2.-
- UniProt
- P0A9H1
- Pockets
- 1 · best druggability 0.66
Structure
x-ray diffraction · 2 distinct chains · 40% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| D | 5'-D(*CP*GP*CP*GP*AP*GP*(AAB)P*TP*CP*GP*CP*G)-3' | dna | 12 | — | — |
| A | G/U mismatch-specific DNA glycosylase (EC 3.2.2.-) | protein | 165 | 40% helix, 18% strand | P0A9H1 |
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 387 | 0.66 | 0.80 | 46 | empty |
Interfaces
1 interface between chains.
- D–A · 201 Ų buried · 5 hydrogen bonds · protein-nucleic
Modifications
Observed in the structure: 1 modified (nucleotide modification).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0A9H1
- Elsewhere: RCSB PDB 1MWI · PDBe 1MWI · UniProt P0A9H1
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