MolNFT v1 · #15173 · protein

Reovirus polymerase LAMBDA3 bound to mRNA cap analog

1MWH · Minor core protein lambda 3: “Reovirus polymerase LAMBDA3 bound to mRNA cap analog”. X-ray diffraction, 2 ligands (GTG, MN), 15 pockets (best druggability 0.77). MolNFT v1 #15173 on GenesisL1: 3D structure, binding sites and pockets…

PDB: 1MWH
Type: protein
Length: 1,256 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Minor core protein lambda 3
UniProt: P17378
Ligands: GTG, MN
Pockets: 15 · best druggability 0.77

Structure

x-ray diffraction · 1 distinct chain · 49% helix, 14% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Minor core protein lambda 3	protein	1256	49% helix, 14% strand	P17378

Ligands and binding sites

GTG · 7-methyl-guanosine-5'-triphosphate-5'-guanosine · ligand · chains A
MN · Manganese (II) ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

15 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	110	0.77	0.96	30	empty
2	1159	0.76	0.79	98	empty
3	56	0.71	0.98	25	empty
4	343	0.62	0.78	43	empty
5	264	0.60	0.79	35	empty

Compared structures

1MWH · Reovirus polymerase LAMBDA3 bound to mRNA cap analog · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P17378
Elsewhere: RCSB PDB 1MWH · PDBe 1MWH · UniProt P17378

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