MolNFT v1 · #151658 · protein
Cryo-EM structure of cardiac amyloid fibrils from an immunoglobulin light chain (al) amyloidosis patient.
6HUD · Monoclonal immunoglobulin light chains (lc): “Cryo-EM structure of cardiac amyloid fibrils from an immunoglobulin light chain (al) amyloidosis patient.”. Electron microscopy, 7 pockets (best druggability 0.77). MolNFT v1 #151658 on…
- PDB
- 6HUD
- Type
- protein
- Length
- 385 residues
- Chains
- 5
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Monoclonal immunoglobulin light chains (lc)
- Pockets
- 7 · best druggability 0.77
Structure
electron microscopy · 1 distinct chain · 0% helix, 68% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E | Monoclonal immunoglobulin light chains (lc) | protein | 77 | 0% helix, 68% strand | — |
Pockets
7 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 677 | 0.77 | 0.83 | 60 | empty |
| 2 | 364 | 0.70 | 0.83 | 39 | empty |
| 3 | 211 | 0.69 | 0.87 | 38 | empty |
| 4 | 59 | 0.59 | 0.90 | 27 | empty |
| 5 | 118 | 0.53 | 0.82 | 25 | empty |
Interfaces
9 interfaces between chains.
- B–C · 3429 Ų buried · 106 hydrogen bonds · protein-protein
- D–E · 3427 Ų buried · 104 hydrogen bonds · protein-protein
- A–B · 3414 Ų buried · 105 hydrogen bonds · protein-protein
- C–D · 3408 Ų buried · 100 hydrogen bonds · protein-protein
- C–E · 295 Ų buried · 2 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 5 disulfide (disulfide).
Compared structures
- 6HUD · Cryo-EM structure of cardiac amyloid fibrils from an immunoglobulin light chain (AL)… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 6HUD · PDBe 6HUD
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