MolNFT v1 · #151655 · protein
The competence regulator comr from streptococcus vestibularis in complex with its cognate signaling peptide xip
6HUA · Uncharacterized protein: “The competence regulator comr from streptococcus vestibularis in complex with its cognate signaling peptide…”. X-ray diffraction, 4 pockets (best druggability 0.64). MolNFT v1 #151655 on GenesisL1: 3D…
- PDB
- 6HUA
- Type
- protein
- Length
- 541 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Uncharacterized protein; Xip signaling peptide
- UniProt
- E3CNF6
- Pockets
- 4 · best druggability 0.64
Structure
x-ray diffraction · 3 distinct chains · 68% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Uncharacterized protein | protein | 296 | 69% helix, 0% strand | E3CNF6 |
| B | Uncharacterized protein | protein | 229 | 69% helix, 0% strand | E3CNF6 |
| C, D | Xip signaling peptide | protein | 8 | 38% helix, 0% strand | — |
Pockets
4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 213 | 0.64 | 0.83 | 25 | empty |
| 2 | 226 | 0.53 | 0.77 | 28 | empty |
| 3 | 147 | 0.51 | 0.79 | 21 | empty |
| 4 | 119 | 0.42 | 0.76 | 20 | empty |
Interfaces
3 interfaces between chains.
- A–B · 1034 Ų buried · 10 hydrogen bonds · protein-protein
- A–C · 942 Ų buried · 10 hydrogen bonds · protein-protein
- B–D · 925 Ų buried · 10 hydrogen bonds · protein-protein
Compared structures
- 6HUA · the competence regulator ComR from Streptococcus vestibularis in complex with its cognate… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt E3CNF6
- Elsewhere: RCSB PDB 6HUA · PDBe 6HUA · UniProt E3CNF6
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