MolNFT v1 · #151624 · protein

Sulfolobus solfataricus tryptophan synthase B2A

6HTE · Tryptophan synthase beta chain 2: “Sulfolobus solfataricus tryptophan synthase B2A”. X-ray diffraction, 1 ligand (PLP), 8 pockets (best druggability 0.81). MolNFT v1 #151624 on GenesisL1: 3D structure, binding sites and pockets in…

PDB: 6HTE
Type: protein
Length: 820 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Tryptophan synthase beta chain 2
EC: 4.2.1.20
UniProt: Q97TX6
Ligands: PLP
Pockets: 8 · best druggability 0.81

Structure

x-ray diffraction · 2 distinct chains · 44% helix, 19% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
B	Tryptophan synthase beta chain 2 (EC 4.2.1.20)	protein	405	43% helix, 19% strand	Q97TX6
D	Tryptophan synthase beta chain 2 (EC 4.2.1.20)	protein	415	44% helix, 18% strand	Q97TX6

Ligands and binding sites

PLP · Pyridoxal-5'-phosphate · ligand · 2 copies · chains B, D
PEG · Di(hydroxyethyl)ether · additive · chains B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

8 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	609	0.81	0.86	70	PLP
2	645	0.81	0.86	67	PLP
3	114	0.79	0.97	23	empty
4	282	0.61	0.79	41	empty
5	70	0.49	0.83	17	empty

Interfaces

1 interface between chains.

B–D · 2320 Å² buried · 17 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 cofactor (pyridoxal phosphate Schiff base).

Compared structures

6HTE · Sulfolobus solfataricus Tryptophan Synthase B2a · the same entry in another collection · chain B against B, TM-score 1.00
Q97TX6 · AlphaFold monomer V2.0 prediction for tryptophan synthase beta chain 2 (Q97TX6) · a predicted model of the same protein · chain B against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q97TX6
Elsewhere: RCSB PDB 6HTE · PDBe 6HTE · UniProt Q97TX6

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.