GL1X · GenesisL1 explorer

MolNFT v1 · #151496 · protein + RNA

Structure of human SRSF1 RRM1 bound to aacaaa RNA

6HPJ · Immunoglobulin G-binding protein G,SERINE/ARGININE-rich…: “Structure of human SRSF1 RRM1 bound to aacaaa RNA”. Solution nmr, 1 pocket (best druggability 0.43). MolNFT v1 #151496 on GenesisL1: 3D structure, binding sites and pockets…

PDB
6HPJ
Type
protein + RNA
Length
90 residues
Chains
2
Method
solution nmr
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule
Immunoglobulin G-binding protein G,SERINE/ARGININE-rich splicing factor 1; RNA…
UniProt
P19909, Q07955
Pockets
1 · best druggability 0.43

Structure

solution nmr · 2 distinct chains · 25% helix, 26% strand (DSSP).

ChainMoleculeTypeResiduesSecondary structureUniProt
BImmunoglobulin G-binding protein G,SERINE/ARGININE-rich splicing factor 1protein8425% helix, 26% strandP19909, Q07955
ARNA (5'-R(*AP*AP*CP*AP*AP*A)-3')rna6——

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

PocketVolume (ų)DruggabilityBuriednessLining residuesInside
11010.430.7716empty

Interfaces

1 interface between chains.

  • B–A · 895 Ų buried · 19 hydrogen bonds · protein-nucleic

Compared structures

  • 6HPJ · Structure of human SRSF1 RRM1 bound to AACAAA RNA · the same entry in another collection · chain A against A, TM-score 1.00
  • Q07955 · AlphaFold monomer V2.0 prediction for SERINE/ARGININE-rich splicing factor 1 (Q07955) · a predicted model of the same protein · chain B against A, TM-score 0.75
  • P19909 · AlphaFold monomer V2.0 prediction for immunoglobulin G-binding protein G (P19909) · a predicted model of the same protein · chain B against A, TM-score 0.38

Analyse

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.