MolNFT v1 · #151466 · protein
Drosophila NOT4 cbm peptide bound to human CAF40
6HON · CCR4-not transcription complex subunit 9: “Drosophila NOT4 cbm peptide bound to human CAF40”. X-ray diffraction, 2 ligands (NA, CL), 6 pockets (best druggability 0.56). MolNFT v1 #151466 on GenesisL1: 3D structure, binding sites and…
- PDB
- 6HON
- Type
- protein
- Length
- 592 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- CCR4-not transcription complex subunit 9; CCR4-not transcription complex subunit 4…
- UniProt
- Q92600, M9PCL9
- Ligands
- NA, CL
- Pockets
- 6 · best druggability 0.56
Structure
x-ray diffraction · 2 distinct chains · 74% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | CCR4-not transcription complex subunit 9 | protein | 271 | 75% helix, 0% strand | Q92600 |
| B, D | CCR4-not transcription complex subunit 4, isoform L | protein | 25 | 60% helix, 0% strand | M9PCL9 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 205 | 0.56 | 0.79 | 27 | empty |
| 2 | 112 | 0.43 | 0.77 | 19 | empty |
| 3 | 138 | 0.42 | 0.74 | 18 | empty |
| 4 | 92 | 0.37 | 0.76 | 22 | empty |
| 5 | 57 | 0.35 | 0.79 | 16 | empty |
Interfaces
3 interfaces between chains.
- C–D · 1117 Ų buried · 10 hydrogen bonds · protein-protein
- A–B · 1026 Ų buried · 8 hydrogen bonds · protein-protein
- A–C · 963 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 6HON · Drosophila NOT4 CBM peptide bound to human CAF40 · the same entry in another collection · chain C against C, TM-score 1.00
- Q92600 · AlphaFold monomer V2.0 prediction for CCR4-not transcription complex subunit 9 (Q92600) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q92600
- Every structure of UniProt M9PCL9
- Elsewhere: RCSB PDB 6HON · PDBe 6HON · UniProt Q92600 · UniProt M9PCL9
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