MolNFT v1 · #151398 · RNA

Solution structure of the RNA duplex formed by the 5'-end of U1SNRNA and the 5'-splice site of SMN2 EXON7 in complex with the smn-C5 splicing modifier

6HMO · RNA (5'-R(*AP*UP*AP*CP*(PSU)P*(PSU)P*AP*CP*CP*UP*G)-3'): “Solution structure of the RNA duplex formed by the 5'-end of U1SNRNA and the 5'-splice site of SMN2 EXON7 in…”. Solution nmr, 1 ligand (GDZ). MolNFT v1 #151398 on GenesisL1…

PDB: 6HMO
Type: RNA
Length: 22 nucleotides
Chains: 2
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: RNA (5'-R(*AP*UP*AP*CP*(PSU)P*(PSU)P*AP*CP*CP*UP*G)-3'); RNA…
Ligands: GDZ

Structure

solution nmr · 2 distinct chains.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	RNA (5'-R(APUPAPCP(PSU)P(PSU)PAPCPCPUP*G)-3')	rna	11	—	—
B	RNA (5'-R(GPGPAPGPUPAPAPGPUPCP*U)-3')	rna	11	—	—

Ligands and binding sites

GDZ · 2-(8-fluoranyl-2-methyl-imidazo[1,2-a]pyridin-6-yl)-7-(4-methylpiperazin-1-yl)pyrido[1,2-a]pyrimidin-4-one · ligand · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

1 interface between chains.

A–B · 513 Å² buried · 40 hydrogen bonds · nucleic-nucleic

Modifications

Observed in the structure: 2 modified (nucleotide modification).

Compared structures

6HMO · Solution structure of the RNA duplex formed by the 5'-end of U1snRNA and the 5'-splice… · the same entry in another collection · chain B against B, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 6HMO · PDBe 6HMO

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