MolNFT v1 · #151370 · protein
Crystal structure of human ACBD3 gold domain in complex with 3A protein of enterovirus-A71 (fusion protein)
6HLW · Golgi resident protein GCP60: “Crystal structure of human ACBD3 gold domain in complex with 3A protein of enterovirus-A71 (fusion protein)”. X-ray diffraction, 2 pockets (best druggability 0.47). MolNFT v1 #151370 on GenesisL1: 3D…
- PDB
- 6HLW
- Type
- protein
- Length
- 326 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Golgi resident protein GCP60; Genome polyprotein
- EC
- 3.4.22.29, 3.6.1.15, 3.4.22.28, 2.7.7.48
- UniProt
- Q9H3P7, A0A023ZRZ0
- Pockets
- 2 · best druggability 0.47
Structure
x-ray diffraction · 4 distinct chains · 17% helix, 44% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Golgi resident protein GCP60 | protein | 124 | 8% helix, 54% strand | Q9H3P7 |
| B | Genome polyprotein (EC 3.4.22.29, 3.6.1.15, 3.4.22.28, 2.7.7.48) | protein | 40 | 48% helix, 13% strand | A0A023ZRZ0 |
| C | Golgi resident protein GCP60 | protein | 121 | 7% helix, 55% strand | Q9H3P7 |
| D | Genome polyprotein (EC 3.4.22.29, 3.6.1.15, 3.4.22.28, 2.7.7.48) | protein | 41 | 46% helix, 17% strand | A0A023ZRZ0 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 91 | 0.47 | 0.80 | 13 | empty |
| 2 | 82 | 0.39 | 0.78 | 14 | empty |
Interfaces
3 interfaces between chains.
- C–D · 1418 Ų buried · 23 hydrogen bonds · protein-protein
- A–B · 1356 Ų buried · 24 hydrogen bonds · protein-protein
- B–D · 349 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 6HLW · Crystal structure of human ACBD3 GOLD domain in complex with 3A protein of… · the same entry in another collection · chain A against A, TM-score 1.00
- Q9H3P7 · AlphaFold monomer V2.0 prediction for golgi resident protein GCP60 (Q9H3P7) · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9H3P7
- Every structure of UniProt A0A023ZRZ0
- Elsewhere: RCSB PDB 6HLW · PDBe 6HLW · UniProt Q9H3P7 · UniProt A0A023ZRZ0
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