MolNFT v1 · #151368 · protein

Crystal structure of the lrr-roc-cor domain of the chlorobium tepidum roco protein

6HLU · Rab family protein: “Crystal structure of the lrr-roc-cor domain of the chlorobium tepidum roco protein”. X-ray diffraction, 20 pockets (best druggability 0.87). MolNFT v1 #151368 on GenesisL1: 3D structure, binding sites and…

PDB: 6HLU
Type: protein
Length: 1,804 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Rab family protein
UniProt: Q8KC98
Pockets: 20 · best druggability 0.87

Structure

x-ray diffraction · 2 distinct chains · 30% helix, 17% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Rab family protein	protein	908	30% helix, 18% strand	Q8KC98
B	Rab family protein	protein	896	29% helix, 17% strand	Q8KC98

Pockets

20 pockets found on a 1 Å grid, 10 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1134	0.87	0.88	113	empty
2	435	0.71	0.82	56	empty
3	381	0.70	0.82	48	empty
4	182	0.58	0.81	20	empty
5	302	0.58	0.78	34	empty

Interfaces

1 interface between chains.

A–B · 2217 Å² buried · 17 hydrogen bonds · protein-protein

Compared structures

6HLU · Crystal structure of the LRR-Roc-COR domain of the Chlorobium tepidum Roco protein · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8KC98
Elsewhere: RCSB PDB 6HLU · PDBe 6HLU · UniProt Q8KC98

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