MolNFT v1 · #151302 · protein
Crystal structure of glutathione transferase omega 1C from trametes versicolor
6HJS · Uncharacterized protein: “Crystal structure of glutathione transferase omega 1C from trametes versicolor”. X-ray diffraction, 1 ligand (GSH), 2 pockets (best druggability 0.77). MolNFT v1 #151302 on GenesisL1: 3D structure, binding…
- PDB
- 6HJS
- Type
- protein
- Length
- 472 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Uncharacterized protein
- UniProt
- R7S6N2
- Ligands
- GSH
- Pockets
- 2 · best druggability 0.77
Structure
x-ray diffraction · 1 distinct chain · 53% helix, 8% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Uncharacterized protein | protein | 236 | 53% helix, 8% strand | R7S6N2 |
Ligands and binding sites
- GSH · Glutathione · ligand · 2 copies · chains A, B
- EPE · 4-(2-hydroxyethyl)-1-piperazine ethanesulfonic acid · additive · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1045 | 0.77 | 0.78 | 106 | GSH |
| 2 | 63 | 0.28 | 0.74 | 23 | empty |
Interfaces
1 interface between chains.
- A–B · 864 Ų buried · 7 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 covalent (covalent ligand).
Compared structures
- 6HJS · Crystal structure of glutathione transferase Omega 1C from Trametes versicolor · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt R7S6N2
- Elsewhere: RCSB PDB 6HJS · PDBe 6HJS · UniProt R7S6N2
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