MolNFT v1 · #151277 · protein

Cytochrome P460 from methylococcus capsulatus (bath)

6HIU: “Cytochrome P460 from methylococcus capsulatus (bath)”. X-ray diffraction, 2 ligands (HEC, SO4), 2 pockets (best druggability 0.74). MolNFT v1 #151277 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6HIU
Type: protein
Length: 286 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Cytochrome P460
UniProt: G1UBD9
Ligands: HEC, SO4
Pockets: 2 · best druggability 0.74

Structure

x-ray diffraction · 1 distinct chain · 22% helix, 38% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
B, A	Cytochrome P460	protein	143	22% helix, 38% strand	G1UBD9

Ligands and binding sites

HEC · Heme C · ligand · 2 copies · chains B, A
SO4 · Sulfate ion · ion · chains A
GOL · Glycerol · additive · chains B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	238	0.74	0.88	39	HEC, GOL
2	237	0.72	0.87	36	HEC

Interfaces

1 interface between chains.

B–A · 2003 Å² buried · 23 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 6 cofactor (heme c attachment).

Compared structures

6HIU · Cytochrome P460 from Methylococcus capsulatus (Bath) · the same entry in another collection · chain B against B, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt G1UBD9
Elsewhere: RCSB PDB 6HIU · PDBe 6HIU · UniProt G1UBD9

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