MolNFT v1 · #151172 · protein

Human HSP90 co-chaperone TTC4 C-domain

6HFO · Tetratricopeptide repeat protein 4: “Human HSP90 co-chaperone TTC4 C-domain”. X-ray diffraction, 1 ligand (PO4), 1 pocket (best druggability 0.49). MolNFT v1 #151172 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6HFO
Type: protein
Length: 154 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Tetratricopeptide repeat protein 4
UniProt: O95801
Ligands: PO4
Pockets: 1 · best druggability 0.49

Structure

x-ray diffraction · 1 distinct chain · 26% helix, 31% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Tetratricopeptide repeat protein 4	protein	154	26% helix, 31% strand	O95801

Ligands and binding sites

PO4 · Phosphate ion · ion · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	121	0.49	0.80	21	PO4

Compared structures

6HFO · Human Hsp90 co-chaperone TTC4 C-domain · the same entry in another collection · chain A against A, TM-score 1.00
O95801 · AlphaFold monomer V2.0 prediction for tetratricopeptide repeat protein 4 (O95801) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O95801
Elsewhere: RCSB PDB 6HFO · PDBe 6HFO · UniProt O95801

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