MolNFT v1 · #151170 · protein
HSP90 co-chaperone CNS1 C-domain from saccharomyces cerevisiae
6HFM · HSP70/HSP90 co-chaperone CNS1: “HSP90 co-chaperone CNS1 C-domain from saccharomyces cerevisiae”. X-ray diffraction, 1 ligand (MG), 3 pockets (best druggability 0.71). MolNFT v1 #151170 on GenesisL1: 3D structure, binding sites and…
- PDB
- 6HFM
- Type
- protein
- Length
- 332 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- HSP70/HSP90 co-chaperone CNS1
- UniProt
- P33313
- Ligands
- MG
- Pockets
- 3 · best druggability 0.71
Structure
x-ray diffraction · 2 distinct chains · 33% helix, 27% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | HSP70/HSP90 co-chaperone CNS1 | protein | 165 | 32% helix, 27% strand | P33313 |
| B | HSP70/HSP90 co-chaperone CNS1 | protein | 167 | 35% helix, 27% strand | P33313 |
Ligands and binding sites
- MG · Magnesium ion · metal · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 424 | 0.71 | 0.82 | 46 | empty |
| 2 | 215 | 0.51 | 0.76 | 29 | empty |
| 3 | 155 | 0.51 | 0.78 | 27 | empty |
Interfaces
1 interface between chains.
- A–B · 677 Ų buried · 10 hydrogen bonds · protein-protein
Compared structures
- 6HFM · Hsp90 co-chaperone Cns1 C-domain from Saccharomyces cerevisiae · the same entry in another collection · chain A against A, TM-score 1.00
- P33313 · AlphaFold monomer V2.0 prediction for HSP70/HSP90 co-chaperone CNS1 (P33313) · a predicted model of the same protein · chain B against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P33313
- Elsewhere: RCSB PDB 6HFM · PDBe 6HFM · UniProt P33313
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.