MolNFT v1 · #15115 · protein

Pheromone binding to two rodent urinary proteins revealed by X-ray crystallography

1MUP · Major urinary protein: “Pheromone binding to two rodent urinary proteins revealed by X-ray crystallography”. X-ray diffraction, 2 ligands (TZL, CD), 1 pocket (best druggability 0.82). MolNFT v1 #15115 on GenesisL1: 3D structure…

PDB: 1MUP
Type: protein
Length: 157 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Major urinary protein
UniProt: P02762
Ligands: TZL, CD
Pockets: 1 · best druggability 0.82

Structure

x-ray diffraction · 1 distinct chain · 13% helix, 46% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Major urinary protein	protein	157	13% helix, 46% strand	P02762

Ligands and binding sites

TZL · 2-(sec-butyl)thiazole · ligand · chains A
CD · Cadmium ion · metal · 4 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	141	0.82	0.98	24	TZL

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

1MUP · Pheromone binding to two rodent urinary proteins revealed by X-ray crystallography · the same entry in another collection · chain A against A, TM-score 1.00
P02762 · AlphaFold monomer V2.0 prediction for major urinary protein 6 (P02762) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P02762
Elsewhere: RCSB PDB 1MUP · PDBe 1MUP · UniProt P02762

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