MolNFT v1 · #151053 · protein
Crystal structure of NUMA/LGN hetero-hexamers
6HC2 · G-protein-signaling modulator 2: “Crystal structure of NUMA/LGN hetero-hexamers”. X-ray diffraction, 20 pockets (best druggability 0.71). MolNFT v1 #151053 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6HC2
- Type
- protein
- Length
- 4,874 residues
- Chains
- 24
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- G-protein-signaling modulator 2; Nuclear mitotic apparatus protein 1
- UniProt
- P81274, Q14980
- Pockets
- 20 · best druggability 0.71
Structure
x-ray diffraction · 16 distinct chains · 63% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, O | G-protein-signaling modulator 2 | protein | 365 | 81% helix, 0% strand | P81274 |
| B | Nuclear mitotic apparatus protein 1 | protein | 45 | 0% helix, 0% strand | Q14980 |
| C, G, I, Q | G-protein-signaling modulator 2 | protein | 367 | 81% helix, 0% strand | P81274 |
| D | Nuclear mitotic apparatus protein 1 | protein | 36 | 8% helix, 0% strand | Q14980 |
| E, K, M, U, W | G-protein-signaling modulator 2 | protein | 366 | 81% helix, 0% strand | P81274 |
| F | Nuclear mitotic apparatus protein 1 | protein | 37 | 14% helix, 3% strand | Q14980 |
| H | Nuclear mitotic apparatus protein 1 | protein | 36 | 11% helix, 0% strand | Q14980 |
| J | Nuclear mitotic apparatus protein 1 | protein | 40 | 0% helix, 0% strand | Q14980 |
| L | Nuclear mitotic apparatus protein 1 | protein | 44 | 16% helix, 0% strand | Q14980 |
| N | Nuclear mitotic apparatus protein 1 | protein | 39 | 10% helix, 0% strand | Q14980 |
| P | Nuclear mitotic apparatus protein 1 | protein | 43 | 19% helix, 0% strand | Q14980 |
| R | Nuclear mitotic apparatus protein 1 | protein | 40 | 8% helix, 0% strand | Q14980 |
| S | G-protein-signaling modulator 2 | protein | 362 | 82% helix, 0% strand | P81274 |
| T | Nuclear mitotic apparatus protein 1 | protein | 45 | 0% helix, 0% strand | Q14980 |
| V | Nuclear mitotic apparatus protein 1 | protein | 39 | 18% helix, 0% strand | Q14980 |
| X | Nuclear mitotic apparatus protein 1 | protein | 40 | 8% helix, 0% strand | Q14980 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 623 | 0.71 | 0.79 | 69 | empty |
| 2 | 596 | 0.71 | 0.79 | 80 | empty |
| 3 | 303 | 0.69 | 0.84 | 39 | empty |
| 4 | 390 | 0.69 | 0.81 | 40 | empty |
| 5 | 593 | 0.68 | 0.77 | 57 | empty |
Interfaces
43 interfaces between chains.
- S–T · 1717 Ų buried · 29 hydrogen bonds · protein-protein
- O–P · 1647 Ų buried · 22 hydrogen bonds · protein-protein
- K–L · 1644 Ų buried · 29 hydrogen bonds · protein-protein
- G–H · 1640 Ų buried · 26 hydrogen bonds · protein-protein
- U–V · 1631 Ų buried · 15 hydrogen bonds · protein-protein
Compared structures
- 6HC2 · Crystal structure of NuMA/LGN hetero-hexamers · the same entry in another collection · chain I against I, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P81274
- Every structure of UniProt Q14980
- Elsewhere: RCSB PDB 6HC2 · PDBe 6HC2 · UniProt P81274 · UniProt Q14980
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